Preview
Faculty Mentor
Christa Chatfield
Creation Date
5-2025
Description
Legionella pneumophila, the pathogen responsible for Legionnaires’ disease, persists in man-made water systems by forming biofilms, where amyloid fibrils contribute to stability. However, the specific protein responsible for amyloid formation remains unidentified. This study is the first step in investigating the biochemical makeup of amyloid-forming proteins in L. pneumophila biofilms. Understanding the composition of the amyloid structures can inform strategies for biofilm disruption and Legionella removal, reducing the risk of disease outbreaks. Our research integrates microbiology and public health by addressing a critical gap in Legionella pathogenesis. Progress includes the successful cultivation and preservation of L. pneumophila biofilms, along with methodological improvements with the goal of eventual purification of the amyloid structures. This research has reinforced the importance of persistence, problem-solving, and interdisciplinary collaboration. Moving forward, work continues to purify the amyloid-associated protein from biofilms, with a long-term goal to develop targeted interventions for preventing Legionella contamination in water systems.
Keywords
Legionella pneumophila